T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis

Nanomaterials

Riju Bhavesh¹  Ana V. Lechuga-Vieco¹  Jesús Ruiz-Cabello¹  Fernando Herranz¹ 

[1] Spanish Cardiovascular Research Centre (CNIC) and Spanish Pulmonary Diseases Network (CIBERES) C/Melchor Fernández-Almagro 3, 28029 Madrid, Spain; E-Mails:

关键词: iron oxide nanoparticles;    MRI;    T₁ contrast;    microwave;   

DOI  :  10.3390/nano5041880

来源: mdpi

【 摘 要 】

Iron oxide nanoparticles have long been studied as a T₂ contrast agent in MRI due to their superparamagnetic behavior. T₁-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T₁-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.