Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

Fibers

Richard Garrett¹  Eri Niiyama²  Yohei Kotsuchibashi²  Koichiro Uto²  Mitsuhiro Ebara² 

[1] Department of Chemistry and Physics, La Trobe University, Bundoora, Victoria 3086, Australia; E-Mail:;International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan; E-Mails:

关键词: biodegradable nanofiber;    poly(ε-caprolactone);    imiquimod;    anti-cancer fiber;   

DOI  :  10.3390/fib3040478

来源: mdpi

【 摘 要 】

In this paper we investigate a potential new treatment option for basal cell carcinoma using electrospun polymer nanofibers. Poly(ε-caprolactone) fibers incorporated with the anti-cancer drug imiquimod were successfully produced for the first time. These fibers were characterized and their diffusion release profile tested in vitro. A range of different electrospinning parameters were investigated in order to determine the most effective approach in optimizing the fibers for future in vivo testing. Characterization showed stable and homogeneous distribution of imiquimod. Although the drug was released faster than what would be needed to replicate the current treatment model, this system would ideally allow for a treatment option which reduces side effects and is more convenient for the patient than the current topical treatment.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.