SNPs Array Karyotyping in Non-Hodgkin Lymphoma

Microarrays

Maryam Etebari²  Mohsen Navari²  Pier Paolo Piccaluga¹ 

[1] Department of Experimental, Diagnostic, and Specialty Medicine; Bologna University School of Medicine; Hematopathology Unit, S. Orsola-Malpighi Hospital, Bologna 40138, Italy;

关键词: non-Hodgkin lymphoma;    single nucleotide polymorphism (SNP) array;    genetic aberrations;   

DOI  :  10.3390/microarrays4040551

来源: mdpi

【 摘 要 】

The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome screening at global level in order to find chromosomal aberrations like copy number variants, DNA amplifications, deletions, and also loss of heterozygosity became feasible. In this review, we present an update of the knowledge, gained by SNPs arrays, of the genomic complexity of the most important subtypes of non-Hodgkin lymphomas.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.