The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia

International Journal of Molecular Sciences

Raffaele Frazzi¹ 

关键词: resveratrol;    non-Hodgkin lymphoma;    apoptosis;   

DOI  :  10.3390/ijms15034977

来源: mdpi

【 摘 要 】

Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland