Journal of Developmental Biology | |
Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation | |
Robert M. Kao1  Joel G. Rurik1  Gist H. Farr1  Xiu Rong Dong1  Mark W. Majesky1  Lisa Maves1  Robert W. Dettman2  | |
[1] Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA; E-Mails:Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA; | |
关键词:
cardiomyocyte;
differentiation;
myocardial morphogenesis;
outflow tract;
proepicardium;
zebrafish;
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DOI : 10.3390/jdb3040093 | |
来源: mdpi | |
【 摘 要 】
Proper control of the temporal onset of cellular differentiation is critical for regulating cell lineage decisions and morphogenesis during development. Pbx homeodomain transcription factors have emerged as important regulators of cellular differentiation. We previously showed, by using antisense morpholino knockdown, that Pbx factors are needed for the timely activation of myocardial differentiation in zebrafish. In order to gain further insight into the roles of Pbx factors in heart development, we show here that zebrafish
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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