The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

Nutrients

Chiara Saponaro¹  Melania Gaggini¹  Fabrizia Carli¹ 

[1] Cardiometabolic Risk Unit, Institute of Clinical Physiology, CNR, via Moruzzi, 1 56124 Pisa, Italy;

关键词: lipotoxicity;    lipolysis;    de novo lipogenesis;    glyceroneogenesis;    fatty liver;    NAFLD;    ectopic fat;    HCC;    SCD-1;    saturated fat;   

DOI  :  10.3390/nu7115475

来源: mdpi

【 摘 要 】

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.