Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats

International Journal of Molecular Sciences

Jung-Bo Huh¹  Joo-Hyun Kim¹  Soyun Kim³  So-Hyoun Lee¹  Kyung Mi Shim²  Se Eun Kim²  Seong Soo Kang²  Chang-Mo Jeong¹ 

[1] Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea;Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea;School of Dentistry, Pusan National University, YangSan 676-870, Korea;

关键词: biocompatibility;    efficacy;    PMMA;    hydroxypropyl methylcellulose;    hyaluronic acid;    filler;    oral submucosa;    cranial subcutaneous;    rat;   

DOI  :  10.3390/ijms161226112

来源: mdpi

【 摘 要 】

This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (n = 10 in each group). The site of cranial subcutaneous injection was the mid-point of the interpupillary line, and the site of intraoral submucosal injection was the ridge crest 2 mm below the cervical line of the mandibular left incisor. Before and immediately after filler injection, intraoral photos and lateral cephalometric radiographs were taken for analysis and comparison of the effect of the filler on the injection sites. The filler injected areas were converted into sequential size changes (%) of the baseline. Histomorphologic examination was performed after 12 weeks. The smallest value in the filler injected area was observed during the experimental period in the normal saline group (p < 0.001), which was almost absorbed at 4 weeks (7.19% ± 12.72%). The HA group exhibited a steady decrease in sequential size and showed a lower value than the DiHM and PDiHM groups (saline < HA < DHiM, PDHiM, p < 0.001). DiHM and PDiHM tended to increase for the first 4 weeks and later decreased until 12 weeks. In this study on DiHM and PDiHM, there was no histological abnormality in cranial skin and oral mucosa. DiHM and PDiHM filler materials with injection system provide an excellent alternative surgical method for use in oral and craniofacial fields.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.