Exact Likelihood Calculation under the Infinite Sites Model

Computation

Muhammad Faisal¹  Andreas Futschik³  Claus Vogl² 

[1] Faculty of Health Studies, University of Bradford, Bradford BD71DP, UK; E-Mail:;Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria;Institute of Applied Statistics, Johannes Kepler University Linz, 4040 Linz, Austria; E-Mail:

关键词: likelihood inference;    population genetics;    dynamic programming;    scaled mutation rate;    population demography;   

DOI  :  10.3390/computation3040701

来源: mdpi

【 摘 要 】

A key parameter in population genetics is the scaled mutation rate . In this case, the ancestral and current θ need to be estimated, as well as the time of change. To our knowledge, this is the first accurate computation of a likelihood in the infinite sites model with non-equilibrium demography.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.