Effect of Different Manufacturing Methods on the Conflict between Porosity and Mechanical Properties of Spiral and Porous Polyethylene Terephthalate/Sodium Alginate Bone Scaffolds

Materials

Ching-Wen Lou²  Chien-Lin Huang⁵  Chih-Kuang Chen³  Chi-Fan Liu¹  Shih-Peng Wen⁴  Jia-Horng Lin⁴ 

[1] Office of Physical Education and Sports Affairs, Feng Chia University, Taichung 40724, Taiwan;Institute of Biomedical Engineering and Materials Science, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan;The Polymeric Biomaterials Lab, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 40724, Taiwan;Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 40724, Taiwan;Department of Fiber and Composite Materials, Feng Chia University, Taichung City 40724, Taiwan;

关键词: plied yarns;    braid;    sodium alginate (SA);    bone scaffold;   

DOI  :  10.3390/ma8125488

来源: mdpi

【 摘 要 】

In order to solve the incompatibility between high porosity and mechanical properties, this study fabricates bone scaffolds by combining braids and sodium alginate (SA) membranes. Polyethylene terephthalate (PET) plied yarns are braided into hollow, porous three dimensional (3D) PET braids, which are then immersed in SA solution, followed by cross-linking with calcium chloride (CaCl₂) and drying, to form PET bone scaffolds. Next, SA membranes are rolled and then inserted into the braids to form the spiral and porous PET/SA bone scaffolds. Samples are finally evaluated for surface observation, porosity, water contact angle, compressive strength, and MTT assay. The test results show that the PET bone scaffolds and PET/SA bone scaffolds both have good hydrophilicity. An increasing number of layers and an increasing CaCl₂ concentration cause the messy, loose surface structure to become neat and compact, which, in turn, decreases the porosity and increases the compressive strength. The MTT assay results show that the cell viability of differing SA membranes is beyond 100%, indicating that the PET/SA bone scaffolds containing SA membranes are biocompatible for cell attachment and proliferation.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.