Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

Molecules

Zhang-Hua Sun²  Fa-Liang Liang²  Wen Wu³  Yu-Chan Chen²  Qing-Ling Pan²  Hao-Hua Li²  Wei Ye²  Hong-Xin Liu²  Sai-Ni Li²  Guo-Hui Tan²  Wei-Min Zhang²  John A. Beutler¹ 

[1] State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China;School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China;

关键词: Guignardia mangiferae;    meroterpenoids;    structure identification;    Smilax glabra;    endophytic fungus;   

DOI  :  10.3390/molecules201219890

来源: mdpi

【 摘 要 】

Four new meroterpenoids, guignardones P–S (1–4), and three known analogues (5–7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.