New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

Molecules

Jéssica K. S. Maciel⁵  Otemberg S. Chaves³  Severino G. Brito Filho³  Yanna C. F. Teles⁵  Marianne G. Fernandes³  Temilce S. Assis⁵  Pedro Dantas Fernandes¹  Alberໜio Pereira de Andrade¹  Leonardo P. Felix¹  Tania M. S. Silva²  Nathalia S. M. Ramos²  Girliane R. Silva²  Maria de Fátima Vanderlei de Souza⁵  Derek J. McPhee⁴ 

[1] Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil;Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil;Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil;;Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, BrazilPost-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil;

关键词: Pilosocereus gounellei;    7′-ethoxy-trans-feruloyltyramine;    anti-oxidant activity;   

DOI  :  10.3390/molecules21010011

来源: mdpi

【 摘 要 】

The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside (3a/3b), 13²-hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7′-ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10). Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.