Molecular mechanisms underlying the anti-cancerous action of flavonoids

Current Health Sciences Journal

D.I. HERTZOG¹ 

关键词: lavonoids;    anti-oxidant activity;    signaling pathways;    cell death ;   

DOI  :  10.12865/CHSJ.38.04.01

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Flavonoids are phenol compounds present in the pigments of fruit, vegetables, green tea and red wine. They have anti-allergic, anti-inflammatory, anti-microbial, anti-cancerous, anti-coagulant and anti-cholesterol effects. A few molecular mechanisms through which flavonoids exert their anti-cancer action are presented. One of the molecular mechanisms on which their anti-cancer action is based is their anti-oxidant activity which is exerted through the direct removal of the free radicals, the interaction with cell membranes, or the inhibition of xanthine-oxidase activity, an important source of ROS (radical oxygen species). Another is that by which flavonoids interact with the pathways signaling cell growth and apoptosis. Flavonoids interact with the signaling pathways for PI3-kinase, Akt/Pkb, tyrosine-kinase, P1KC and MAP-kinase. The same flavonoids may alter growth signaling by inhibiting receptor phosphorylation or by arresting growth factors binding to receptors. The activation of a.

【 授权许可】

Unknown