Notch Signaling in Pancreatic Development

International Journal of Molecular Sciences

Xu-Yan Li¹  Wen-Jun Zhai¹  Chun-Bo Teng¹ 

[1] College of Life Science, Northeast Forestry University, Harbin 150040, China;

关键词: pancreatic progenitor;    Notch signaling;    differentiation;    maintenance;   

DOI  :  10.3390/ijms17010048

来源: mdpi

【 摘 要 】

The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.