Role of Notch signaling in the mammalian heart

Brazilian Journal of Medical and Biological Research

X.l. Zhou¹  J.c. Liu¹ 

关键词: Notch signaling;    Congenital heart disease;    Myocardial regeneration;    Cardioprotection;    Angiogenesis;    Cardiac fibroblast-myofibroblast transformation;   

DOI  :  10.1590/1414-431X20133177

来源: SciELO

【 摘 要 】

Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation. This review provides an update on the known roles of Notch signaling in the mammalian heart. The goal is to assist in developing strategies to influence Notch signaling and optimize myocardial injury repair.

【 授权许可】

CC BY   
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