The Effect of Stromal Integrin β3-Deficiency on Two Different Tumors in Mice

Cancers

Inga Reigstad¹  Kristina Sortland¹  Trude Skogstrand¹  Rolf K. Reed¹  Linda Stuhr¹ 

[1]Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway

关键词: angiogenesis;    fibrosis;    interstitial fluid pressure;    metastasis;    tumor growth;   

DOI  :  10.3390/cancers8010014

来源: mdpi

【 摘 要 】

There is an increasing focus on the tumor microenvironment in carcinogenesis. Integrins are important receptors and adhesion molecules in this environment and have been shown to be involved in cell adhesion, proliferation, differentiation and migration. The present study aimed to evaluate the effect of stromal integrin β3-deficiency on tumor growth, angiogenesis, interstitial fluid pressure (PIF), fibrosis and metastasis in a murine breast cancer (4T1) and a prostate tumor (RM11) model. We showed that stromal integrin β3-deficiency led to an elevation in PIF that correlated to a shift towards thicker collagen fibrils in the 4T1 mammary tumor. In the RM11 prostate carcinoma model there was no effect of integrin β3-deficiency on PIF and collagen fibril thickness. These findings support the notion that changes in the collagen scaffold influence PIF, and also indicate that there must be important crosstalk between the stroma and tumor cells, in a tumor cell line specific manner. Furthermore, stromal integrin β3-deficiency had no effect on tumor growth or angiogenesis in both tumor models and no effect on lung metastasis in the 4T1 mammary tumor model. In conclusion, the stromal β3 integrin influence PIF, possibly via its effect on the structure of the collagen network, in a tumor cell line dependent manner.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.