Individuals with Metabolically Healthy Overweight/Obesity Have Higher Fat Utilization than Metabolically Unhealthy Individuals

Nutrients

Arturo Pujia³  Carmine Gazzaruso²  Yvelise Ferro³  Elisa Mazza³  Samantha Maurotti³  Cristina Russo³  Veronica Lazzaro¹  Stefano Romeo³ 

[1] Department of Health Science, University Magna Grecia, Catanzaro 88100, Italy;Clinical Institute “Beato Matteo”, Vigevano 27029, Italy;Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy;

关键词: obesity;    nutrition assessment;    fat utilization;    Metabolic Syndrome;    metabolically unhealthy Obesity;    diabetes;   

DOI  :  10.3390/nu8010002

来源: mdpi

【 摘 要 】

The mechanisms underlying the change in phenotype from metabolically healthy to metabolically unhealthy obesity are still unclear. The aim of this study is to investigate whether a difference in fasting fat utilization exists between overweight/obese individuals with a favorable cardiovascular risk profile and those with Metabolic Syndrome and Type 2 diabetes. Furthermore, we sought to explore whether there is an association between fasting fat utilization and insulin resistance. In this cross-sectional study, 172 overweight/obese individuals underwent a nutritional assessment. Those with fasting glucose ≥126 mg/dL or antidiabetic treatment were considered to be diabetics. If at least three of the NCEP criteria were present, they had Metabolic Syndrome, while those with less criteria were considered to be healthy overweight/obese. An indirect calorimetry was performed to estimate Respiratory Quotient, an index of nutrient utilization. A lower Respiratory Quotient (i.e., higher fat utilization) was found in healthy overweight/obese individuals than in those with Metabolic Syndrome and Type 2 diabetes (0.85 ± 0.05; 0.87 ± 0.06; 0.88 ± 0.05 respectively, p = 0.04). The univariate and multivariable analysis showed a positive association between the Respiratory Quotient and HOMA-IR (slope in statistic (B) = 0.004; β = 0.42; p = 0.005; 95% Confidence interval = 0.001–0.006). In this study, we find, for the first time, that the fasting Respiratory Quotient is significantly lower (fat utilization is higher) in individuals who are metabolically healthy overweight/obese than in those with metabolically unhealthy obesity. In addition, we demonstrated the association between fat utilization and HOMA-IR, an insulin resistance index.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.