Evaluation of the Nano-TiO2 as a Novel Deswelling Material

Molecules

Ming Chu¹  Yue-Long Hou¹  Lan Xu¹  Zheng-Yun Chu²  Ming-Bo Zhang²  Yue-Dan Wang¹ 

[1] Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China;Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China;

关键词: nano-TiO₂;    nitric oxide;    deswelling activity;    vascular permeability;    nano-TiO₂ ointment;   

DOI  :  10.3390/molecules21010057

来源: mdpi

【 摘 要 】

Nano-TiO₂ is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO₂ has not been reported. Here, we demonstrated that nano-TiO₂ can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO₂ exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO₂ ointment and observed similar deswelling effects. In conclusion, nano-TiO₂ might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.