Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation

Nutrients

Lisa J. Moran¹  Victoria Tsagareli¹  Manny Noakes² 

[1] The Robinson Research Institute, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide 5006, South Australia, Australia;CSIRO Food and Nutritional Sciences, Adelaide 5000, South Australia, Australia;

关键词: in-vitro fertilization;    weight loss;    diet;    exercise;    pregnancy;    fertility;    assisted reproductive technology;    unsaturated fat;    omega 3 fatty acids;   

DOI  :  10.3390/nu8010010

来源: mdpi

【 摘 要 】

Maternal preconception diet is proposed to affect fertility. Prior research assessing the effect of altering the fatty acid profile on female fertility is conflicting. The aim of this study was to assess the effect of preconception maternal diet, specifically fatty acid profile, on pregnancies and live births following in vitro fertilisation (IVF). Forty-six overweight and obese women undergoing IVF were randomised to a diet and physical activity intervention (intervention) or standard care (control). Outcome measures included pregnancy, live birth and pre-study dietary intake from food frequency questionnaire. Twenty pregnancies (n = 12/18 vs. n = 8/20, p = 0.12) and 12 live births (n = 7/18 vs. n = 5/20, p = 0.48) occurred following the intervention with no differences between the treatment groups. On analysis adjusted for BMI and smoking status, women who became pregnant had higher levels of polyunsaturated fatty acid (PUFA) intake (p = 0.03), specifically omega-6 PUFA and linoleic acid (LA) (p = 0.045) with a trend for an elevated intake of omega-3 PUFA (p = 0.06). There were no dietary differences for women who did or did not have a live birth. Maternal preconception PUFA, and specifically omega-6 and LA intake, are associated with improved pregnancy rates in overweight and obese women undergoing IVF. This has implications for optimising fertility through preconception nutrition.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.