Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

Marine Drugs

Yu-Chia Chang⁶  Liang-Mou Kuo³  Tsong-Long Hwang⁵  Jessica Yeh¹  Zhi-Hong Wen⁶  Lee-Shing Fang⁴  Yang-Chang Wu²  Chan-Shing Lin⁶  Jyh-Horng Sheu⁶  Ping-Jyun Sung⁷ 

[1] Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan;Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan;Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan;Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan;;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan

关键词: secosterol;    gorgonian;    Pinnigorgia;    anti-inflammatory;    superoxide anion;    elastase;    cytotoxicity;    HSCs;   

DOI  :  10.3390/md14010012

来源: mdpi

【 摘 要 】

Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

【 授权许可】

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.