Synthesis of Isotopically Labeled 13C3-Simazine and Development of a Simultaneous UPLC-MS/MS Method for the Analysis of Simazine in Soil

Molecules

Yan Song²  Yangzhen Guo²  Xia Zhang²  Yue Yang²  Shuo Chen²  Gaimei She¹  Dongmei She² 

[1]School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China

[2]Plant Protection Institute of the Chinese Academy of Agricultural Sciences, Beijing 100193, China

关键词: ¹³C₃-simazine;    synthesis;    IDMS;    UPLC-MS/MS;    isotope labelling;   

DOI  :  10.3390/molecules21010089

来源: mdpi

【 摘 要 】

The isotope dilution mass spectrometry (IDMS) is a highly efficient method for tackling the ion suppression in complex matrix by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), but a lack of commercial internal standards is a limiting factor for these analyses. Herein, an economical and efficient strategy for the synthesis of ¹³C₃-simazine via a three-step procedure was developed. The isotope-labeled internal standard was used for determination of simazine residue in soil samples. The quantitation method has a limit of detection of 0.015 μg/kg and quantitation of 0.08 μg/kg. The inter-day and intra-day precision of the method were below 4.6%. Recovery values were ranged between 92.9% and 99.2%. All the samples obtained from six provinces in China contained from 1 to 62 μg/kg of simazine.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.