Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization

International Journal of Molecular Sciences

Patrick Maier¹  Linda Hartmann²  Frederik Wenz²  Carsten Herskind² 

[1] Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany

关键词: radiotherapy;    radioresistance;    radiosensitization;    double strand break;    DNA repair;    apoptosis;    mitotic catastrophe;    senescence;   

DOI  :  10.3390/ijms17010102

来源: mdpi

【 摘 要 】

During the last few decades, improvements in the planning and application of radiotherapy in combination with surgery and chemotherapy resulted in increased survival rates of tumor patients. However, the success of radiotherapy is impaired by two reasons: firstly, the radioresistance of tumor cells and, secondly, the radiation-induced damage of normal tissue cells located in the field of ionizing radiation. These limitations demand the development of drugs for either radiosensitization of tumor cells or radioprotection of normal tissue cells. In order to identify potential targets, a detailed understanding of the cellular pathways involved in radiation response is an absolute requirement. This review describes the most important pathways of radioresponse and several key target proteins for radiosensitization.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.