The mass-action law based algorithm for cost-effective approach for cancer drug discovery and development

American Journal of Cancer Research

Ting-Chao Chou¹ 

关键词: Drug discovery;    drug development;    unified theory for dose-effect pharmacodynamics;    median-effect equation and plot of the mass-action law;    drug combination;    combination index;    synergy definition;    econo-green revolution for bio-research;    experimental design;    computer simulation;    diagnostic plot;    therapeutic cure of xenograft tumor;    ardeemin and immunosuppression;    iso-oxazole-fludelone and epothilones;    small size experiment;    conservation of animals;    pharmacodynamics;    dose-reduction index;    polygonogram;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

The mass-action law based system analysis via mathematical induction and deduction lead to the generalized theory and algorithm that allows computerized simulation of dose-effect dynamics with small size experiments using a small number of data points in vitro, in animals, and in humans. The median-effect equation of the mass-action law deduced from over 300 mechanism specific-equations has been shown to be the unified theory that serves as the common-link for complicated biomedical systems. After using the median-effect principle as the common denominator, its applications are mechanism-independent, drug unit-independent, and dynamic order-independent; and can be used generally for single drug analysis or for multiple drug combinations in constant-ratio or non-constant ratios. Since the “median” is the common link and universal reference point in biological systems, these general enabling lead to computerized quantitative bio-informatics for econo-green bio-research in broad disciplines. Specific applications of the theory, especially relevant to drug discovery, drug combination, and clinical trials, have been cited or illustrated in terms of algorithms, experimental design and computerized simulation for data analysis. Lessons learned from cancer research during the past fifty years provide a valuable opportunity to reflect, and to improve the conventional divergent approach and to introduce a new convergent avenue, based on the mass-action law principle, for the efficient cancer drug discovery and the low-cost drug development.

【 授权许可】

Unknown