Genetic association between the HIF-1α P582S polymorphism and cervical cancer risk: a meta analysis

International Journal of Clinical and Experimental Pathology

Youfei Li¹  Rongkai Xie¹  Zhengqiong Chen¹  Xiang Cheng¹  Jing Zhu¹  Guilan Lin¹  Ying Yang¹  Jianmei Liu¹ 

关键词: HIF-1α;    cervical cancer;    polymorphism;    risk;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Background: Hypoxia-inducible factor-1 alpha (HIF-1α) P582S polymorphism has been reported to increase transactivation capacity of HIF-1α, which is prone to tumorigenesis. Several published case-control studies on the association between P582S polymorphism and cervical cancer have shown mixed results. In this study, we chose to perform a meta-analysis to assess the association. Methodology/Principal findings: We conducted a meta-analysis consisting of four studies with a total of 846 cases and 991 controls. All data were collected and overall comparison was performed among all subjects. Using the fi xed effects model, the homozygous and the recessive models showed a significant increase in the risk of cervical cancer (the pooled OR=6.32, 95% CI=2.28-17.55, Phet=0.348; the pooled OR=5.86, 95% CI=2.13-16.11, Phet=0.394 respectively). Publication bias was not significantly indicated in this analysis. Conclusions: This meta-analysis demonstrates that HIF-1α P582S polymorphism may be associated with the risk of cervical cancer.

【 授权许可】

Unknown