Ratio of prostate specific antigen to the outer gland volume of prostrate as a predictor for prostate cancer

International Journal of Clinical and Experimental Pathology

Yang Yan¹  Guang-Hui Hu¹  Jun-Hua Zheng¹  Fang Wang¹  Wen-Yu Gu¹  Hai-Min Zhang¹ 

关键词: Prostate cancer;    prostate specific antigen;    benign prostate hyperplasia;    prostate specific antigen density;    outer gland of the prostate;    diagnosis;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: As a definite diagnosis of prostate cancer, puncture biopsy of the prostate is invasive method. The aim of this study was to evaluate the value of OPSAD (the ratio of PSA to the outer gland volume of prostate) as a non-invasive screening and diagnosis method for prostate cancer in a select population. Methods: The diagnosis data of 490 subjects undergoing ultrasound-guided biopsy of the prostate were retrospectively analyzed. This included 133 patients with prostate cancer, and 357 patients with benign prostate hyperplasia (BPH). Results: The OPSAD was significantly greater in patients with prostate cancer (1.87 ± 1.26 ng/ml²) than those with BPH (0.44 ± 0.21 ng/ml²) (P < 0.05). Receiver operating characteristic (ROC) curve analysis revealed that the performance of OPSAD as a diagnostic tool is superior to PSA and PSAD for the diagnosis of prostate cancer. In the different groups divided according to the Gleason score of prostate cancer, OPSAD is elevated with the rise of the Gleason score. Conclusion: OPSAD may be used as a new indicator for the diagnosis and prognosis of prostate cancer, and it can reduce the use of unnecessary puncture biopsy of the prostate.

【 授权许可】

Unknown