Comparing of IRS and Her2 as immunohistochemical scoring schemes in gastroenteropancreatic neuroendocrine tumors

International Journal of Clinical and Experimental Pathology

Merten Hommann¹  Luisa Peter¹  Richard Paul Baum¹  Daniel Kaemmerer¹  Stefan Schulz¹  Jörg Sänger¹  Vikas Prasad¹  Amelie Lupp¹ 

关键词: Gastroenteropancreatic neuroendocrine tumors;    somatostatin receptors;    UMB-1 antibody;    immunohistochemistry;    IRS;    Her2-score;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Neuroendocrine tumors (NET) are known for an overexpression of somatostatin receptors (SSTR). In light of very few and partially contradictory publications, the present study aims to achieve a definite immunohistochemical (IHC) quantification and assessment of the distribution of all five SSTR-subtypes on NET and to evaluate an implementable scoring system, comparing the immunoreactive score of Remmele and Stegner (IRS) to the Her2-score. In 21 patients 40 different tumor tissues were IHC analysed using polyclonal antibodies for SSTR1 and 3-5 and the monoclonal antibody UMB-1 for SSTR2A. SSTR expression was quantitatively evaluated according to HER2-score and IRS, correlated among each other and to the maximum standardized uptake value (SUVmax) in tumor lesions as measured by PET/CT using 68Ga-DOTA-NOC.

【 授权许可】

Unknown