An uncommon case of de novo CD10+ CD5− mantle cell lymphoma mimics follicle center B cell lymphoma

International Journal of Clinical and Experimental Pathology

Mauricio Zapata¹  Rodolfo Bordoni¹  Shiyong Li¹  Steven D Budnick¹ 

关键词: Mantle cell lymphoma;    follicular lymphoma;    germinal center B cell;    CD10;    CD5;    BCL1;    Cyclin D1;    fluorescence in situ hybridization;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by expression of CD5, overexpres-sion of Cyclin D1 as a result of chromosomal translocation t(11;14)(q13;q32), and poor prognosis. Cases of MCL lacking CD5 expression as well as cases with coexpression of CD5 and CD10 have also been reported. Here we describe an uncommon case of de novo MCL with expression of CD10, but not CD5, mimicking lymphoma of germinal center-derived B cells. The lymphoma cells in this case demonstrated a diffuse pattern of proliferation, and were strongly positive for Cyclin D1 by immunohistochemical stain. Fluorescence in situ hybridization studies demonstrated the presence of t(11;14)(q13;q32) involving BCL1, but not chromosomal translocations involving C-MYC or BCL2, confirming the diagnosis of MCL. This case further highlights the importance of comprehensive immunopheno-typic and genetic characterization in the diagnosis and classification of B-cell lymphomas.

【 授权许可】

Unknown