L-Arginine and Alzheimer's Disease

International Journal of Clinical and Experimental Pathology

Xudong Huang¹  Jack T. Rogers¹  Laura L. Horky¹  Ying Shi¹  Avi L. Friedlich¹  Jing Yi¹ 

关键词: L-arginine;    nitric oxide synthase;    nitric oxide;    arginase;    polyamines;    neurogenesis;    stem cells;    Alzheimer's disease;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Alzheimer's disease (AD), the most common form of dementia, is characterized by progressive neurodegeneration and loss of cognitive and memory functions. Although the exact causes of AD are still unclear, evidence suggests that atherosclerosis, redox stress, inflammation, neurotransmitter dysregulation, and impaired brain energy metabolism may all be associated with AD pathogenesis. Herein, we explore a possible role for L-arginine (L-arg) in AD, taking into consideration known functions for L-arg in atherosclerosis, redox stress and the inflammatory process, regulation of synaptic plasticity and neurogenesis, and modulation of glucose metabolism and insulin activity. L-arg, a precursor of nitric oxide and polyamine, exhibits multiple functions in human health and may play a prominent role in age-related degenerative diseases such as AD.

【 授权许可】

Unknown