Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling

American Journal of Translational Research

Thorsten Berger¹  Erfei Song¹  Bo Yang¹  Aimin Xu¹  Tak W Mak¹  Jessie WS Yue¹  Yu Wang¹  Karen SL Lam¹  Gary Sweeney¹  Hung-Fat Tse¹  Pengcheng Fan¹  Paul M Vanhoutte¹ 

关键词: Lipocalin-2;    adipokine;    heart;    mitochondria;    phospholipids;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Recent clinical and experimental evidences demonstrate an association between augmented circulating lipocalin-2 [a pro-inflammatory adipokine] and cardiac dysfunction. However, little is known about the pathophysi-ological role of lipocalin-2 in heart. The present study was designed to compare the heart functions of mice with normal (WT) or deficient lipocalin-2 (Lcn2-KO) expression.

【 授权许可】

Unknown