American Journal of Translational Research | |
Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer | |
Marja T Nevalainen1  Zhiyong Liao1  | |
关键词: Prostate cancer; therapy development; prolactin receptor-Jak2-Stat5a/b signaling pathway; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Signal transducer and activator of transcription 5 (Stat5) is critical for the viability and growth of human prostate cancer cells in culture and for prostate xenograft tumors in nude mice. The expression of nuclear active Stat5a/b is associated with high histological grades of clinical prostate cancers, and the presence of active Stat5a/b in prostate cancer predicts early disease recurrence. Stat5a/b and androgen receptor signaling pathways functionally synergize in prostate cancer cells, and recent work suggests that Stat5a/b may be involved in the progression of prostate cancer to metastatic disease. Here, we review the biological functions of Stat5a/b in prostate cancer and potential strategies to target the prolactin receptor (PrlR)/Jak2/Stat5 signaling pathway for therapy development for prostate cancer.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140865680ZK.pdf | 246KB | download |