Association between vitamin D receptor gene polymorphisms and breast cancer in a Chinese population

International Journal of Clinical and Experimental Medicine

Xiaopin Chen¹  Xin Jiang¹  Fan Li¹  Bingjun Guo¹  Xiaoqiao Hu¹ 

关键词: Vitamin D receptor;    haplotype;    genotype;    breast cancer;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: The present study aimed to explore the association between vitamin D receptor (VDR) genetic polymorphisms and breast cancer risk. Methods: A total of 219 patients with breast cancer and 321 cases of females without breast cancer were enrolled for the present study. PCR-RFLP method was used to genotype 3 SNPs of the VDR gene (rs1544410, rs7975232 and rs731236). ELISA method was used to detect the amount of 1,25(OH)₂D₃ in the plasma. The results were analyzed using SPSS 17.0 software. Results: We found rs7975232 was associated with breast cancer risk. Compared with GG genotype carriers, TT subjects had a lower risk of breast cancer (P = 0. 004, OR = 0.774, 95% CI: 0.212~0.955). However, there was no difference in 1,25(OH)₂D₃ levels among the different genotypes. In addition, the distribution frequency of the haplotype A-G-T in the patients group was 4.4%, significantly higher than the control group (0.7%, P = 0.003; OR=2.643, 95% CI: 1.631~7.012), while the distribution of haplotype G-T-T in the patient group was significantly lower than in the control group (17.3% vs. 28.4%, P = 0.011, OR = 0.543, 95% CI: 0.325~0.854). Conclusions: The VDR gene was associated with breast cancer pathogenesis; females carrying the haplotype G-T-T had a lower breast cancer risk, while the haplotype A-G-T conferred a higher risk.

【 授权许可】

Unknown