Garlic and alpha lipoic supplementation enhance the immune system of albino rats and alleviate implications of pesticides mixtures

International Journal of Clinical and Experimental Medicine

Aly GE Abd El-Aal¹  Sherif H Abd-Alrahman¹  Reem M Ziada¹  Manal EA Elhalwagy¹  Nevine S Darwish¹  Dina A Shokry¹  Abd-Alhamed Nahas¹ 

关键词: Organophosphorus pesticides;    alpha lipoic acid;    garlic;    immunotoxicity;    weaning;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

This study aimed to investigate age dependent immune-system response versus exposure to different doses of mixture of (chlorpyrifos, profenofose, and fenitrothion) and/or combined with 60 and 250 mg kg^-1 alpha lipoic acid and garlic, respectively. 120 males of albino rats were divided to two groups according to age; weaning group (2 months age and 60-80 gm.), adult (6 months and 180-200 gm). Each age was divided into 6 subgroups treated orally for 3 months , G1 (control), G2 high dose (HDPM) CPF10 mg kg^-1, PRO 3 mg kg^-1, FEN 6 mg kg^-1, G3 low dose (LDPM) CPF 1 mg kg^-1, PFN 0.3 mg kg^-1 and FEN 0.6 mg kg^-1, G4 AOX (alpha lipoic + Garlic), G5 HDPM + AOX and G6 LDPM + AOX. Results showed significant inhibition in serum acetylcholinesterase (AChE), elevation in malondialdehyde (MDA) concurrent with reduction in total reduced glutathione (GSH) in both ages was recorded as well as, decrease in IGG, IGM, Lymphocyte transformation and Phagocytosis humeral and cellular immunity confirmed by alteration in lymph nodes architecture. This study was concluded that the supplementation with alpha lipoic acid and garlic improved previous alternations slightly to be more or less near the control level in both adult and weaning rats. It seems that, immune-responses of both adult and weaning rats were slightly similar.

【 授权许可】

Unknown