Vascular endothelial growth factor polymorphisms and lung cancer risk

International Journal of Clinical and Experimental Medicine

Caipeng Lei¹  Jianmin Chen¹  Junli Fan¹  Bin Qiao¹  Hongduo Jiao¹  Shuo Cui¹  Leizhen Jiang¹  Weiguo Zhang¹  Qin Liu¹  Qiang Chen¹ 

关键词: Lung cancer;    VEGF;    meta-analysis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

The VEGF polymorphisms has been implicated in the susceptibility to lung cancer, but the results are not conclusive. The aim of this study is to investigate the association between the VEGF polymorphisms and the risk of lung cancer by meta-analysis. We searched PubMed, Embase, CNKI and Wanfang databases. A total of 7 case-control studies were included in this meta-analysis. We found that VEGF rs833061 polymorphism showed no significant association with lung cancer risk. Subgroup analysis on race suggested that CC genotype was significantly associated with lung cancer risk in Asian population. We found that VEGF rs699947 polymorphism showed significant association with lung cancer risk. Subgroup analysis on race showed that VEGF rs699947 polymorphism increased lung cancer risk in Asians. In conclusion, this meta-analysis suggested that the VEGF rs699947 is associated with increased risk of lung cancer.

【 授权许可】

Unknown