Correlation of serum uric acid with bone mineral density and fragility fracture in patients with primary osteoporosis: a single-center retrospective study of 253 cases

International Journal of Clinical and Experimental Medicine

Lin Chen¹  Yongde Peng¹  Ling Pan¹  Jinyu Chen¹  Li You¹  Fang Fang¹ 

关键词: Osteoporosis;    fractures;    bone density;    uric acid;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: This study aimed to investigate the correlation of serum uric acid with bone mineral density (BMD) and fragility fracture in primary osteoporosis (PO) patients. Methods: A retrospective analysis of biochemical parameters including bone turnover markers and bone density was done in patients (n=253) received initial treatment for PO from January 2011 to May 2012 at the Shanghai First People’s Hospital. Results: Pearson correlation analysis and multiple regression analysis showed that serum uric acid positively correlated with the lumbar spine BMD (P<0.05); serum uric acid negatively correlated with urine calcium/creatinine ratio, but positively correlated with blood 25-hydroxyvitamin D (25 [OH] D) (P<0.05); the serum uric acid in postmenopausal women with the history of fragility fracture was significantly lower than that in women without the this disease history. Conclusion: Serum uric acid may be a protective factor of bone metabolism in primary osteoporosis patients.

【 授权许可】

Unknown