MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis

International Journal of Clinical and Experimental Medicine

Haiyan Chen¹  Hongye Dong¹  Aili Jiang¹  Guijiang Sun¹  Bo Li¹  Lan Jia¹  Lihua Wang¹  Xueqing Bi¹  Haibo Yu¹  Fang Wei¹  Haiyan Pang¹  Lin Wang¹  Zhe Wang¹  Jia Meng¹  Ruining Zhang¹ 

关键词: Diabetic nephropathy;    MTHFR polymorphisms;    type 2 diabetes;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Background: Many studies have suggested a correlation between the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and diabetic nephropathy (DN), but their results are inconclusive. Methods: To confirm this correlation, we performed a meta-analysis of 15 studies. The dichotomous data are presented as odds ratios (OR) with 95% confidence intervals (CI). Results: The results of this study suggested that the MTHFR 677 T allele was more likely to increase the risk of DN in Asian (OR = 1.466, 95% CI = 1.143-1.880, P = 0.003), West Asian (OR = 1.750, 95% CI = 1.150-2.664, P = 0.009), and Chinese populations (OR = 2.162, 95% CI = 1.719-2.719, P = 0.001), but not in East Asian or Japanese populations. The carriers of the MTHFR 677 T allele were associated with progression of DN in the “5-10 year duration” group, but not in the “> 10 year duration” group (OR = 2.187, 95% CI = 1.787-2.677, P = 0.001). Conclusion: Development of DN is associated with MTHFR C677T polymorphisms in Asian populations, especially in early type 2 diabetes.

【 授权许可】

Unknown