International Journal of Clinical and Experimental Medicine | |
Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats | |
Fariborz Samini1  Mohsen Azimin-Nezhad1  Saeed Samarghandian1  Tahereh Farkhondeh1  | |
关键词: Chrysin; nociception; noradrenalin; corticosterone; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Objective: The levels of corticosterone and noradrenalin as the two nociception modulators modify after stress condition. The propose of current study was to investigate the effect of chrysin on formalin-induced nociceptive behaviors and serum levels of corticosterone and noradrenalin in rats. Materials and methods: Pain was induced by applying 20 μL of 5% formalin in distilled water in the subplantar of the right hind paw. Chrysin (50, 100 and 150 mg/kg, intraperitoneally (i.p.) was administered 60 min before formalin injection. Morphine (10 mg/kg, i.p.) was administered 30 min before formalin injection. The control group received the same volume of saline by i.p. injection 30 min before formalin injection. Results: Chrysin treatment can significantly decrease formalin-induced pain in rat in a dose-dependent manner. Chrysin (150 mg/kg) significantly inhibit the first phase (P < 0.01), whereas, the all concentration of chrysin were affected on the later phase of formalin-induced pain (P < 0.05). Chrysin could significantly attenuate the content of corticosterone and noradrenalin in the serum versus to the control rats (P < 0.01). Conclusion: The current study confirms that the chrysin decreased the nociceptive behaviors in the formalin test and indicate a correlation with decrease in serum corticosterone and noradrenalin levels.
【 授权许可】
Unknown
【 预 览 】
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RO201912140864808ZK.pdf | 334KB | download |