IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection

International Journal of Clinical and Experimental Medicine

Jincheng Zeng¹  Zhifeng Chen¹  Qingchun Yuan¹  Guoqiang Huang¹  Ruiqin Li¹  Zhichao Xie¹ 

关键词: Enterovirus 71;    neurologic pulmonary edema;    Hand food mouth disease (HFMD);    pro-inflammatory;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

In the present study, the aim was to reveal the relationship of serum IL-6, IL-10 and IL-13 levels in patient with Enterovirus 71 (EV71) infection. To elucidate the role of immune mechanisms in the pathogenesis of Hand, foot, and mouth disease (HFMD), we analyzed the cytokine of 112 EV71-infected patients. A significant elevation of serum (interleukin) IL-6, IL-10 and IL-13 levels in patients with EV71 infection compare with Un-EV71 infection HFMD patient and Healthy individuals. The production of inflammatory cytokines was increased with disease clinical stage. In addition, the immunological consequences of these cytokine in patient with EV71 infection showed a downward trend after cure. These data suggested that EV71 infection significantly increased the release of circulating IL-6, IL-10 and IL-13. The systemic inflammatory response may play an important role in the pathogenesis of HFMD. Moreover, this study may be designed to evaluate the potential therapeutic of medicine in the treatment of patients with EV71 infection.

【 授权许可】

Unknown