Relationship of osteopontin and renal function with severity of coronary artery lesions

International Journal of Clinical and Experimental Medicine

Yachen Zhang¹  Jian Chen¹  Damin Huang¹  Xiaohan Luo¹  Yingmin Lu¹ 

关键词: Osteopontin;    renal failure;    coronary heart disease;    atherosclerosis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Aim: To explore the relationship of plasma osteopontin (OPN) level and renal function with severity of coronary artery lesions. Methods: OPN level and renal function were detected and compared in 210 patients with coronary heart disease (CHD group) and 134 patients without coronary heart disease (control group) to analyze the relationship of osteopontin and renal function with severity of coronary artery lesions. Results: Plasma OPN and creatinine level were significantly higher in CHD group than those in control group (P<0.01), and estimated glomerular filtration rate (eGFR) was lower in CHD group than that in control group (P<0.01). The proportions of multi-vessel lesion and moderate to severe decreased renal function were higher in patients with high osteopontin than those in patients with low osteopontin (P<0.05), and the proportion of multi-vessel lesion was higher in patients with moderate to severe decreased renal function than that in normal renal function (P<0.05). Osteopontin and renal failure were the independent risk factors for coronary heart disease. Conclusions: Plasma OPN level is associated with renal failure, both of which are correlated with the severity of coronary artery lesions.

【 授权许可】

Unknown