MicroRNA-19a promotes glioma cell growth by repressing LRIG1

International Journal of Clinical and Experimental Medicine

Qian-Xue Chen¹  Yue-Fei Wang¹  Peng Wu¹  Ji-Qiang Li¹  Ling-Min Shao¹  Ji-An Yang¹ 

关键词: miRNA-19a;    LRIG1;    glioma;    proliferation;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Growing evidence indicates that deregulation of miRNAs contributes to the development of glioma. In present study, we found that the level of miRNA-19a was significantly elevated in glioma tissues and cell lines. Moreover, down-regulation of miRNA-19a dramatically repressed glioma cell growth in vitro and in vivo. Meanwhile, the expression of LRIG1, a tumor suppressor in glioma, was increased following miRNA-19a knockdown. Furthermore, luciferase reporter assay confirmed that LRIG1 was a direct target of miRNA-19a. In addition, silencing of LRIG1 could reverse the suppressive effect of miRNA-19a inhibitor. Taken together, our results demonstrated that down-regulation of miRNA-19a could suppress the growth of glioma cells, at least in part, through up-regulating LRIG1.

【 授权许可】

Unknown