Frequencies of HFE gene mutations associated with haemochromatosis in the population of Libya living in Benghazi

International Journal of Clinical and Experimental Medicine

Ron A Dixon¹  Samir Elmrghni¹  D Ross Williams¹ 

关键词: HFE gene mutations;    H63D;    C282Y;    haemochromatosis;    allele frequency;    Benghazi;    Libyan population;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

The studies of the HFE mutations: H63D and C282Y in North African populations have revealed the extreme rarity or even the absence of the C282Y mutation. We have examined 200 chromosomes (100 Libyan people live in Benghazi) for the presence of the two HFE mutations by PCR-RFLP analysis by using PCR conditions used to amplify both Autosomal and Y chromosomal STRs. We have found that the allele frequencies are, respectively, 17% for the H63D and 0% for the C282Y. These results are consistent with the worldwide spread of the H63D mutation and the north European restriction of the C282Y.

【 授权许可】

Unknown