Induction of antigen-specific immune tolerance by TGF-β-induced CD4+Foxp3+ regulatory T cells

International Journal of Clinical and Experimental Medicine

Song Guo Zheng¹  Huimin Fan¹  Julie Wang¹  Zhongmin Liu¹  Xiaohui Zhou¹ 

关键词: TGF-β;    Foxp3;    regulatory T cells;    Immunoregulation;    transplant tolerance;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Like natural CD4⁺CD25⁺ Treg cells, TGF-β-induced Treg cells also prevent allograft rejection in MHC-mismatched organ transplantation models. In analyzing this effect with greater detail, we determined that injection of TGF-β-induced, alloactivated CD4⁺CD25⁺ cells induces antigen-specific immune tolerance in vivo. Increased CD4⁺CD25⁺ cells in recipients contribute to this immune tolerance. In addition, adoptive transfer of TGF-β-induced CD4⁺CD25⁺ cells did not result in significant toxic and side effects in recipients. These results indicate that TGF-β-induced, alloactivated CD4⁺CD25⁺ cells may provide a safe and effective approach to protect MHC-mismatched organ grafts from rejection in a clinical setting.

【 授权许可】

Unknown