Critical role for thymic CD19+CD5+CD1dhiIL‐10+ regulatory B cells in immune homeostasis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: regulatory T cells;    Foxp3;    CD72;   

DOI  :  10.1189/jlb.3A0414-213RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thisstudytestedthehypothesisthatbesidesthespleen,LNs,peripheralblood,andthymuscontainaregulatoryIL‐10‐producingCD19+CD5+CD1dhighBcellsubsetthatmayplayacriticalroleinthemaintenanceofimmunehomeostasis.Indeed,thispopulationwasidentifiedinthemurinethymus,andfurthermore,whencoculturedwithCD4+Tcells,thispopulationofBcellssupportedthemaintenanceofCD4+Foxp3+Tregsinvitro,inpart,viatheCD5–CD72interaction.MicehomozygousforCd19Cre(CD19−/−)expressBcellswithimpairedsignalingandhumoralresponses.Strikingly,CD19−/−miceproducefewerCD4+Foxp3+TregsandagreaterpercentageofCD4+CD8−andCD4−CD8+Tcells.Consistentwiththeseresults,transferofthymicCD19+CD5+CD1dhiBcellsintoCD19−/−miceresultedinsignificantlyup‐regulatednumbersofCD4+Foxp3+TregswithaconcomitantreductioninCD4+CD8−andCD4−CD8+Tcellpopulationsinthethymus,spleen,andLNsbutnotintheBMofrecipientmice.Inaddition,thymicCD19+CD5+CD1dhiBcellssignificantlysuppressedautoimmuneresponsesinlupus‐likemiceviaup‐regulationofCD4+Foxp3+TregsandIL‐10‐producingBregs.ThisstudysuggeststhatthymicCD19+CD5+CD1dhiIL‐10+Bregsplayacriticalroleinthemaintenanceofimmunehomeostasis...

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