Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: a meta-analysis

International Journal of Clinical and Experimental Medicine

Dongfeng Tan¹  Ming Yin¹  Qingyi Wei¹ 

关键词: DNA repair gene;    esophageal cancer;    genetic polymorphism;    meta-analysis;    molecular epidemiology;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

To summarize published data on the role of common genetic variants of the X-ray repair cross-complementing group 1 (XRCC1) gene in susceptibility to esophageal cancer (EC), we performed a meta-analysis including 11 eligible publications with 3,306 patients and 6,852 controls for Arg³⁹⁹Gln and 832 patients and 1,418 controls for Arg¹⁹⁴Trp. Overall, the variant Gln³⁹⁹ allele was not associated with EC risk, compared with the Arg³⁹⁹ allele in the populations included in the analysis. However, stratified analysis revealed that Gln³⁹⁹ allele was associated with an increased EC risk among Chinese populations in a recessive model (OR, 1.33; 95% CI 1.01–1.76; fixed effects) and by homozygote contrast (OR, 1.35; 95% CI 1.01–1.81), particularly for the tumor histology of squamous cell carcinoma (OR, 1.34; 95% CI 1.03–1.73 for the recessive model) and (OR, 1.34; 95% CI 1.02–1.76 for the homozygote contrast). There was no apparent effect of the Trp¹⁹⁴ allele, compared to the Arg¹⁹⁴ allele, on the EC risk in all analyses. These results suggest that the XRCC1 Arg³⁹⁹Gln polymorphism may be a potential biomarker of EC susceptibility in Chinese populations, particularly for squamous cell carcinoma. Further larger studies with multi-ethnic populations are required to further assess the association between XRCC1 polymorphisms and EC risk.

【 授权许可】

Unknown