Asthma and Pulmonary Function Abnormalities in Heterozygotes for Cystic Fibrosis Transmembrane Regulator Gene Mutations

International Journal of Clinical and Experimental Medicine

Konstantinos Douros¹  Ioanna Loukou¹  Kostas N. Priftis¹  Maria Tzetis¹  Emmanuel Kanavakis¹  Stavros Doudounakis¹ 

关键词: Asthma;    cystic fibrosis transmembrane regulator gene mutations;    cystic fibrosis heterozygosity;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

The aim of our study is to evaluate the association between CFTR gene mutations with asthma and pulmonary function abnormalities. For this purpose, 214 mutation carriers were compared to 185 non-carriers. Although the relative risk of asthma did not differ between groups (OR=0.61, 95% CI: 0.23–1.61, p=0.32), the values of FEV1, and FEV1/FVC ratio were lower in carriers (p=0.001, and p<0.001, respectively). This may imply that heterozygosity may be related with a silent obstructive pulmonary profile.

【 授权许可】

Unknown