期刊论文详细信息
BMC Complementary and Alternative Medicine
Integrated traditional Chinese medicine for childhood asthma in Taiwan: a Nationwide cohort study
Wen-Long Hu3  Ying-Jung Tseng2  Bei-Yu Wu2  Chih-Hsin Muo4  Mao-Feng Sun5  I-Ling Hung2  Yu-Chiang Hung1 
[1]School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan
[2]Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Kaohsiung, Taiwan
[3]Fooyin University College of Nursing, Kaohsiung, Taiwan
[4]Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
[5]China Medical University College of Chinese Medicine, Taichung, Taiwan
关键词: Hospitalization;    Emergency;    Asthma;    Traditional Chinese medicine;   
Others  :  1086140
DOI  :  10.1186/1472-6882-14-389
 received in 2014-06-28, accepted in 2014-10-06,  发布年份 2014
PDF
【 摘 要 】

Background

Traditional Chinese medicine (TCM) is the most commonly used alternative therapy in children with asthma, especially in the Chinese community. This study aimed to investigate the effects of the government-sponsored Outpatient’s Healthcare Quality Improvement (OHQI) project with integrated TCM treatment on childhood asthma.

Methods

This study used the Longitudinal Health Insurance Database 2000, which is a part of the Taiwan National Health Insurance Research Database (NHIRD). Children with diagnosed asthma and aged under 15 years from 2006–2010 were enrolled. They were collated into 3 groups: (1) subjects treated with non-TCM; (2) subjects treated with single TCM; and (3) subjects treated with integrative OHQI TCM. The medical visits and the cost of treatment paid by the Bureau of National Health Insurance (BNHI) to the outpatient, emergency room, and inpatient departments were evaluated for the study subjects within 1 year of the first asthma diagnosis during the study period.

Results

Fifteen multi-hospitals, including 7 medical centers, and 35 TCM physicians participated in OHQI during the study period. A total of 12850 children from the NHIRD database were enrolled in this study, and divided as follows: 12435 children in non-TCM group, 406 children in single TCM group, and 9 children in integrative OHQI TCM group. Although the total medical cost paid by the BNHI per patient in the integrative OHQI TCM group was greater than that in the non-OHQI groups, the patients in the integrative OHQI TCM group exhibited greater therapeutic effects, and did not require ER visits or hospitalization. In addition, ER visits and hospitalization among patients who received a combination of conventional therapy with integrated TCM were lower than those among patients who underwent conventional therapy alone or single TCM treatment.

Conclusions

Asthmatic children at partly controlled level under conventional therapy may benefit from adjuvant treatment with integrated TCM.

【 授权许可】

   
2014 Hung et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20150113183512120.pdf 195KB PDF download
Figure 1. 48KB Image download
【 图 表 】

Figure 1.

【 参考文献 】
  • [1]Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ: Status of childhood asthma in the United States, 1980–2007. Pediatrics 2009, 123(suppl 3):S131-S145.
  • [2]Akinbami LJ, Schoendorf KC: Trends in childhood asthma prevalence, health care utilization, and mortality. Pediatrics 2002, 110:315-322.
  • [3]Wu LS, Sjakste T, Sakalauskas R, Sitkauskiene B, Paramonova N, Gasiuniene E, Jan RL, Wang JY: The burden of allergic asthma in children: a landscape comparison based on data from Lithuanian, Latvian, and Taiwanese populations. Pediatr Neonatol 2012, 53:276-282.
  • [4]Yeh KW, Ou LS, Yao TC, Chen LC, Lee WI, Huang JL: PATCH Study Group: Prevalence and risk factors for early presentation of asthma among preschool children in Taiwan. Asian Pac J Allergy Immunol 2011, 29:120-126.
  • [5]Yangzong Y, Shi Z, Nafstad P, Håheim LL, Luobu O, Bjertness E: The prevalence of childhood asthma in China: a systematic review. BMC Public Health 2012, 12:860. BioMed Central Full Text
  • [6]Delmas MC, Fuhrman C: Pour le groupe épidémiologie et recherche clinique de la SPLF: Asthma in France: a review of descriptive epidemiological data. Rev Mal Respir 2010, 27:151-159.
  • [7]Zhao J, He Q, Zhang G, Chen Q, Bai J, Huang Y, Chen Q, Ni C, Huang S, Tang S, Li Y, Zheng H, Bin B, Chen S, Zhu X, Liu C, Zhang S, Zhang Y, Zhou X, Lin R, Zhao S, Hao C, Li M, Sun J, Li Y, Chen F, Shen Z, Hou W, Cheng H, Gao Y, et al.: Status of asthma control in children and the effect of parents’ knowledge, attitude, and practice (KAP) in China: a multicenter study. Ann Allergy Asthma Immunol 2012, 109:190-194.
  • [8]Jones BP, Paul A: Management of acute asthma in the pediatric patient: an evidence-based review. Pediatr Emerg Med Pract 2013, 10:1-23. quiz 23–4
  • [9]Wang JY, Liu LF: Health care utilization and medical costs for childhood asthma in Taiwan: using Taiwan National Health Insurance Research Database. Asia Pac Allergy 2012, 2:167-171.
  • [10]Grover C, Armour C, Asperen PP, Moles R, Saini B: Medication use in children with asthma: not a child size problem. J Asthma 2011, 48:1085-1103.
  • [11]Kim CY, Park HW, Ko SK, Chang SI, Moon HB, Kim YY, Cho SH: The financial burden of asthma: a nationwide comprehensive survey conducted in the republic of Korea. Allergy Asthma Immunol Res 2011, 3:34-38.
  • [12]Sennhauser FH, Braun-Fahrländer C, Wildhaber JH: The burden of asthma in children: a European perspective. Paediatr Respir Rev 2005, 6:2-7.
  • [13]Labre MP, Herman EJ, Dumitru GG, Valenzuela KA, Cechman CL: Public health interventions for asthma: an umbrella review, 1990–2010. Am J Prev Med 2012, 42:403-410.
  • [14]Weng HC: Impacts of a government-sponsored outpatient-based disease management program for patients with asthma: a preliminary analysis of national data from Taiwan. Dis Manag 2005, 8:48-58.
  • [15]Adams A, Saglani S: Difficult-to-treat asthma in childhood. Paediatr Drugs 2013, 15:171-179.
  • [16]Karaca-Mandic P, Jena AB, Joyce GF, Goldman DP: Out-of-pocket medication costs and use of medications and health care services among children with asthma. JAMA 2012, 307:1284-1291.
  • [17]Torres-Llenza V, Bhogal S, Davis M, Ducharme F: Use of complementary and alternative medicine in children with asthma. Can Respir J 2010, 17:183-187.
  • [18]Shen J, Oraka E: Complementary and alternative medicine (CAM) use among children with current asthma. Prev Med 2012, 54:27-31.
  • [19]Alshagga MA, Al-Dubai SA, Muhamad Faiq SS, Yusuf AA: Use of complementary and alternative medicine among asthmatic patients in primary care clinics in Malaysia. Ann Thorac Med 2011, 6:115-119.
  • [20]Philp JC, Maselli J, Pachter LM, Cabana MD: Complementary and alternative medicine use and adherence with pediatric asthma treatment. Pediatrics 2012, 129:e1148-e1154.
  • [21]George M, Topaz M: A systematic review of complementary and alternative medicine for asthma self-management. Nurs Clin North Am 2013, 48:53-149.
  • [22]Kligler B, McKee MD, Sackett E, Levenson H, Kenney J, Karasz A: An integrative medicine approach to asthma: who responds? J Altern Complement Med 2012, 8:939-945.
  • [23]Kopnina H: Alternative treatment for asthma: case study of success of traditional Chinese medicine treatment of children from urban areas with different levels of environmental pollution. ISRN Allergy 2012, 2012:547534.
  • [24]Li XM, Brown L: Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol 2009, 123:297-306. quiz 307–8
  • [25]Kim DY, Yang W: Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model. J Ethnopharmacol 2011, 136:230-235.
  • [26]Gu PC, Fan XS, Jiang CX, Xu HQ, Yu JH, Tang YP: Effect of San’ao Decoction on the airway inflammation and hyperresponsiveness in a murine model of lipopolysaccharide-enhanced asthma. Chin J Integr Med 2011, 17:537-541.
  • [27]Kelly-Pieper K, Patil SP, Busse P, Yang N, Sampson H, Li XM, Wisnivesky JP, Kattan M: Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med 2009, 15:735-743.
  • [28]Singh BB, Khorsan R, Vinjamury SP, Der-Martirosian C, Kizhakkeveettil A, Anderson TM: Herbal treatments of asthma: a systematic review. J Asthma 2007, 44:685-698.
  • [29]Wen BL, Liu BY, Jin P, Wang XF, Xiang XX, Liu XF, Hu JQ, Lu F, He LY, Zhu WZ, Fang YG, Wang Y: Clinical research of acupoint application for ‘treatment of winter disease in summer’ used to prevent and treat bronchial asthma in children. J Tradit Chin Med 2012, 32:31-39.
  • [30]Yu L, Zhang Y, Chen C, Cui HF, Yan XK: Meta-analysis on randomized controlled clinical trials of acupuncture for asthma. Zhongguo Zhen Jiu 2010, 30:787-792.
  • [31]Fattah MA, Hamdy B: Pulmonary functions of children with asthma improve following massage therapy. J Altern Complement Med 2011, 17:1065-1068.
  • [32]Wen BL, Zhou H, Liu BY, Sun GJ, Liu WH, Peng J, Hu JQ, He LY, Fang YG, Zi MJ: Analysis on acupoint prescription for acupoint sticking therapy of treating winter diseases in summer for preventing and curing chronic cough and asthma. Zhongguo Zhen Jiu 2010, 30:647-652.
  • [33]Yao H, Tong J, Zhang PD, Tao JP, Li JX: Acupoint sticking therapy for treatment of bronchial asthma: a multicenter controlled randomized clinical trial. Zhongguo Zhen Jiu 2009, 29:609-612.
  • [34]Tai CJ, Chang CP, Huang CY, Chien LY: Efficacy of Sanfujiu to treat allergies: patient outcomes at 1 year after treatment. Evid Based Complement Alternat Med 2007, 4:241-246.
  • [35]Arnold E, Clark CE, Lasserson TJ, Wu T: Herbal interventions for chronic asthma in adults and children. Cochrane Database Syst Rev 2008, CD005989. doi:10.1002/14651858.CD005989.pub2
  • [36]Hondras MA, Linde K, Jones AP: Manual therapy for asthma. Cochrane Database Syst Rev 2005, CD001002. doi:10.1002/14651858.CD001002.pub2
  • [37]McCarney RW, Brinkhaus B, Lasserson TJ, Linde K: Acupuncture for chronic asthma. Cochrane Database Syst Rev 2003, CD000008. doi:10.1002/14651858.CD000008.pub2
  • [38]Han J: Observation on effect of acupuncture at Yuji (LU 10) on the pulmonary function of patients with bronchial asthma and immediate efficacy of relieving asthma. Zhongguo Zhen Jiu 2012, 32:891-894.
  • [39]Balon JW, Mior SA: Chiropractic care in asthma and allergy. Ann Allergy Asthma Immunol 2004, 93(2 Suppl 1):S55-S60.
  • [40]Maas T, Kaper J, Sheikh A, Knottnerus JA, Wesseling G, Dompeling E, Muris JW, van Schayck CP: Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev 2009, CD006480. doi:10.1002/14651858.CD006480.pub2
  • [41]Wang SD, Lin LJ, Chen CL, Lee SC, Lin CC, Wang JY, Kao ST: Xiao-Qing-Long-Tang attenuates allergic airway inflammation and remodeling in repetitive Dermatogoides pteronyssinus challenged chronic asthmatic mice model. J Ethnopharmacol 2012, 142:531-538.
  • [42]Chang RS, Wang SD, Wang YC, Lin LJ, Kao ST, Wang JY: Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. BMC Complement Altern Med 2013, 13:220. BioMed Central Full Text
  • [43]Chan CK, Kuo ML, Shen JJ, See LC, Chang HH, Huang JL: Ding Chuan Tang, a Chinese herb decoction, could improve airway hyper-responsiveness in stabilized asthmatic children: a randomized, double-blind clinical trial. Pediatr Allergy Immunol 2006, 17:316-322.
  • [44]Tan C, Zhao JP, Zhang C: Survey of clinical and experimental researches on mechanisms of acupuncture treatment of bronchial asthma. Zhen Ci Yan Jiu 2011, 36:302-306. 312
  • [45]Wu ZL, Li CR, Liu ZL, Zhang QR: Effects of acupuncture at ‘Zusanli’ (ST 36) on eosinophil apoptosis and related gene expression in rats with asthma. Zhongguo Zhen Jiu 2012, 32:721-725.
  • [46]Li YM, Liu Q, Li XY: New percutaneous absorption herbal patch for asthma of paracmasis and its effect on the relative transcription factors of patients. Zhongguo Zhen Jiu 2012, 32:459-463.
  文献评价指标  
  下载次数:14次 浏览次数:39次