Cholinergic Modulation of Inflammation

International Journal of Clinical and Experimental Medicine

Valentin A. Pavlov¹ 

关键词: Inflammation;    inflammatory diseases;    cytokines;    vagus nerve;    α7nAChR;    cholinergic anti-inflammatory pathway;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Recent studies have demonstrated that cytokine levels and inflammation can be regulated by specifically augmenting cholinergic signaling via the efferent vagus nerve and the α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR). Cholinergic modalities, acting through vagus nerve- and/or α7nAChR-mediated mechanisms have been shown to suppress excessive inflammation in several experimental models of disease, including endotoxemic shock, sepsis, ischemia-reperfusion injury, hemorrhagic shock, colitis, postoperative ileus and pancreatitis. These studies have advanced the current understanding of the mechanisms regulating inflammation. They have also provided a rationale for exploring new possibilities to treat excessive, disease-underlying inflammation by applying selective cholinergic modalities in preclinical and clinical settings. An overview of this research is presented here.

【 授权许可】

Unknown