Lanostane tetracyclic triterpenoids as important sources for anti-inflammatory drug discovery

World Journal of Traditional Chinese Medicine

article

Yu-Pei Yang¹  Shumaila Tasneem²  Muhammad Daniyal¹  Liu Zhang¹  Yan-Zhe Jia¹  Yu-Qing Jian¹  Bin Li¹  Wei Wang¹ 

[1] School of Pharmacy, TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Drug Research Institute, Hunan University of Chinese Medicine;School of Pharmacy, TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Drug Research Institute, Hunan University of Chinese Medicine, Changsha, China, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences. Gulzar-e-Hijri

关键词: Inflammation;    inflammatory diseases;    lanostane triterpenoids;    rheumatoid arthritis;   

DOI  :  10.4103/wjtcm.wjtcm_17_20

学科分类：内科医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Inflammation is a defensive reaction of the human body to numerous detrimental stimuli, including physical trauma, noxious chemicals, as well as microbial agents. Uncontrolled inflammation is the pathological basis of multiple diseases, such as rheumatoid arthritis (RA), neurodegenerative diseases, liver disease, and lung inflammation. Lanostane triterpenoids are natural tetracyclic triterpenoids with significant anti-inflammatory activity. An extensive review of the published literature regarding the phytochemistry and anti-inflammatory pharmacology of lanostane triterpenoids has been performed and analyzed using several search engines, such as SciFinder, Web of Science, Scopus, PubMed, Google Scholar, and ScienceDirect. This review is devoted to naturally occurring lanostane-type triterpenes with anti-inflammatory activity, including their sources, biosynthesis, and mechanism of action. This review also discusses the inflammation-related diseases and the clinical significance of traditional Chinese medicine as multi-target therapeutic agents for the prevention and treatment of inflammatory diseases. In the past 30 years, more than 100 new lanostane-type triterpenes have been reported from the families Schisandraceae, Ganodermataceae, and Polyporaceae. Six compounds, fomitopinic acid A, fomitosides E and F, obtusifoliol, 4α, l4α-dimethyl-5α-ergosta-7,9(11), 24(28)-trien-3 β-ol, and gramisterol exhibited the most potent anti-inflammatory activity against cyclooxygenase-1 (COX-1) and COX-2, with IC 50 values ranging from 0.087 to 1.15 μM. Some of these compounds exhibited significant activity by mediating the inhibition of the pro-inflammatory cytokines, inducible nitric oxide synthase, and COX-2 expression. This review provides a basis for identifying anti-inflammatory drugs with high selectivity, high potency, and few adverse effects from lanostane-type triterpenes.

【 授权许可】

CC BY-NC-SA