RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics

International Journal of Biochemistry and Molecular Biology

Anne-Marie Bonneau¹  Elias Georges¹  Panagiotis Prinos¹ 

关键词: α-enolase;    knockdown;    chemotherapeutic drugs;    antitubulin chemotherapeutics;    sensitivity;    cancer;    RNAi;    A549;    H460 lung;    MCF7 breast;    CaOV3;   

DOI  :  

学科分类：生物化学/生物物理

来源: e-Century Publishing Corporation

【 摘 要 】

The over-expression of α-enolase was demonstrated in several cancers, including lung, brain, breast, colon and prostate. In this report, we investigated the effects of α-enolase knockdown on the sensitivity of cancer cells to chemotherapeutic drugs. RNAi-mediated knockdown of α-enolase in A549 and H460 lung, MCF7 breast and CaOV3 ovarian cancer cells caused a significant increase in the sensitivity of these cells to antitubulin chemotherapeutics (e.g., vincristine and taxol), but not to doxorubicin, etoposide or cisplatinum. This is the first demonstration showing the effects of α-enolase expression on the sensitivity of tumor cells to clinically relevant chemotherapeutics.

【 授权许可】

Unknown