Advances and application of radioimmunotherapy in non-Hodgkin lymphoma

American Journal of Blood Research

Patrick L Stevens¹  Olalekan Oluwole¹  Nishitha Reddy¹ 

关键词: Radioimmunotherapy;    non-Hodgkin lymphoma;    stem cell transplantation;    CD20 target;   

DOI  :  

学科分类：血液学

来源: e-Century Publishing Corporation

【 摘 要 】

The activity of radio-immuno conjugate in Non-Hodgkin Lymphoma (NHL) has resulted in FDA approval of two antibodies, Y⁹⁰ Ibritumomab tiuxetan and I¹³¹ tositumomab. Both these agents target CD20, a receptor widely expressed in B-Cell NHL. These immunoconjugates deliver their radioactive payload to the malignant clone in the bone marrow and lymph node. Their use has been associated with modest improvement in survival end points among several lymphoma histologies. The promising effect on disease control as well as their efficacy in disease relapse is encouraging in low grade lymphoma. Radioimmunotherapy (RIT) is increasingly being explored in the setting of consolidation as well as conditioning regimens prior to stem cell transplantation. Here, we summarize the clinical use, complications and future applications of RIT in NHL.

【 授权许可】

Unknown