Molecular imaging of integrin αvβ6 expression in living subjects

American Journal of Nuclear Medicine and Molecular Imaging

Yue Wu¹  Hao Liu¹  Fan Wang¹  Zhaofei Liu¹ 

关键词: Molecular probe;    noninvasive imaging;    positron emission tomography (PET);    single-photon emission computed tomography (SPECT);    cancer;    fibrosis;    wound healing;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Integrins, a family of cell adhesion molecules composed of α and β heterodimeric subunits, are involved in a wide range of cell-extracellular matrix and cell-cell interactions. The study of integrin family members as targets for molecular imaging and therapy has been generally limited with the exception of integrin α_vβ₃. _vβ₆, a member of the integrin family, is expressed at low or undetectable levels in normal tissues, but is widely upregulated during many pathological and physiological processes, especially cancer and fibrosis, making it a promising target for molecular imaging. Noninvasive and quantitative imaging of integrin _vβ₆ expression would be very useful for disease diagnosis, treatment monitoring, and prognosis assessment. Although various molecular probes have been developed for positron emission tomography and single-photon emission computed tomography imaging of integrin _vβ₆ expression in preclinical animal models, further research efforts are required to optimize integrin _vβ₆-targeting probes for future potential clinical applications in the fields of oncology and beyond.

【 授权许可】

Unknown