In a “nutshell”: intrinsically radio-labeled quantum dots

American Journal of Nuclear Medicine and Molecular Imaging

Hao Hong¹  Weibo Cai¹ 

关键词: Quantum-dots (QDs);    nanoparticle;    positron emission tomography (PET);    single-photon emission computed tomography (SPECT);    near-infrared (NIR);    optical imaging;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Quantum dots (QDs) have many intriguing properties suitable for biomedical imaging applications. The poor tissue penetration of optical imaging in general, including those using QDs, has motivated the development of various QD-based dual-modality imaging agents. In this issue of AJNMMI (http://www.ajnmmi.us), Sun et al. reported the synthesis and in vitro/in vivo characterization of intrinsically radio-labeled QDs (r-QDs), where ¹⁰⁹Cd was incorporated into the core/shell of QDs of various compositions. These r-QDs emit in the near-infrared range, have long circulation half-life, are quite stable with low cytotoxicity, exhibit small size and low accumulation in the reticuloendothelial system, and can allow for accurate measurement of their biodistribution in mice. With these desirable features demonstrated in this study, future development and optimization will further enhance the biomedical potential of intrinsically radio-labeled QDs.

【 授权许可】

Unknown